Non‐enzymatic function of prostasin and sodium balance

Prostasin: An Epithelial Sodium Channel Regulator

Prostasin is a glycophosphatidylinositol-anchored protein which is found in prostate gland, kidney, bronchi, colon, liver, lung, pancreas, and salivary glands. It is a serine protease with trypsin-like substrate specificity which was first purified from seminal fluid in 1994. In the last decade, its diverse roles in various biological and physiological processes have been elucidated. Many studi...

Activation of epithelial sodium channels by prostasin in Xenopus oocytes.

Prostasin, a novel serine protease, was purified from seminal fluid, and its cDNA sequence was determined. Expression of prostasin was detected in human tissues, including prostate, kidney, and lung, as well as bodily fluids, including seminal fluid and urine. However, its physiologic role in the human body is not known. Recently, a novel regulatory mechanism by which serine proteases activate ...

Inhibitors of prostasin

compactifications and function spaces on weighted semigruops

chapter one is devoted to a moderate discussion on preliminaries, according to our requirements. chapter two which is based on our work in (24) is devoted introducting weighted semigroups (s, w), and studying some famous function spaces on them, especially the relations between go (s, w) and other function speces are invesigated. in fact this chapter is a complement to (32). one of the main fea...

164 - Sodium and Water Balance

between the two spaces when water diffuses freely across the membrane. The predominant solute of the extracellular space is sodium. Various disease states may alter water balance and lead to abnormally high or low sodium levels that may result in significant disability or death from either the causative disease, the direct effects of the sodium concentration, or the ill effects of inappropriate...